Edar Signaling in the Control of Hair Follicle Development
نویسندگان
چکیده
منابع مشابه
Wnt Signaling in Hair Follicle Development
HF is a mini-organ formed with mesenchymal-epithelial interaction (Schmidt-Ullrich & Paus, 2005). HF development and cycle are depended on signaling between its epidermal and dermal components. Especially, dermal organizing center, DP, is both chemical and physical niche for epithelial stem cells. DP plays an important role in HF induction and cycling by controlling self-renewal and differentia...
متن کاملRegulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar.
X-linked and autosomal forms of anhidrotic ectodermal dysplasia syndromes (HED) are characterized by deficient development of several ectodermal organs, including hair, teeth and exocrine glands. The recent cloning of the genes that underlie these syndromes, ectodysplasin (ED1) and the ectodysplasin A receptor (EDAR), and their identification as a novel TNF ligand-receptor pair suggested a role...
متن کاملEdar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development.
The development of ectodermal organs requires signalling by ectodysplasin (Eda), a tumor necrosis factor (TNF) family member, its receptor Edar and downstream activation of the nuclear factor kappaB (NF-kappaB) transcription factor. In humans, mutations in the Eda pathway components cause hypohidrotic ectodermal dysplasia, a syndrome characterized by missing teeth, sparse hair and defects in sw...
متن کاملSignaling Involved in Hair Follicle Morphogenesis and Development
Hair follicle morphogenesis depends on Wnt, Shh, Notch, BMP and other signaling pathways interplay between epithelial and mesenchymal cells. The Wnt pathway plays an essential role during hair follicle induction, Shh is involved in morphogenesis and late stage differentiation, Notch signaling determines stem cell fate while BMP is involved in cellular differentiation. The Wnt pathway is conside...
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in the area of automotive engineering there is a tendency to more electrification of power train. in this work control of an induction machine for the application of electric vehicle is investigated. through the changing operating point of the machine, adapting the rotor magnetization current seems to be useful to increase the machines efficiency. in the literature there are many approaches wh...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology Symposium Proceedings
سال: 2005
ISSN: 1087-0024
DOI: 10.1111/j.1087-0024.2005.10129.x